Venous neointimal hyperplasia in polytetrafluoroethylene dialysis grafts
نویسندگان
چکیده
منابع مشابه
Severe venous neointimal hyperplasia prior to dialysis access surgery.
BACKGROUND Venous neointimal hyperplasia is the most common cause of arteriovenous (AV) fistula and graft dysfunction following dialysis access surgery. However, the pathogenetic impact of pre-existing venous neointimal hyperplasia at the time of AV access creation on final clinical success is currently unknown in the setting of advanced chronic kidney disease (CKD) and end-stage renal disease ...
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BACKGROUND The main pathology of haemodialysis graft stenosis is venous neointimal hyperplasia at graft-venous anastomoses. Neointimal hyperplasia is also observed in cases of coronary artery in-stent restenosis. Paclitaxel is a chemotherapeutic agent used to treat cancer, and has been proven to inhibit neointimal hyperplasia of coronary artery in-stent restenosis. In this study, we examined wh...
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Autologous saphenous veins are commonly used to circumvent occluded coronary arteries during coronary artery bypass grafting (CABG) procedures.1 Although these vessels provide an effective treatment for myocardial ischemic disease, they are susceptible to accelerated atherosclerosis and fail in 50% of cases within 10 years of surgery.2–4 Venous graft disease occurs via 3 temporally distinct pro...
متن کاملIncreased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts.
Intimal hyperplasia is a primary cause of failure after vascular reconstruction and may be affected by blood flow. We have studied the effects of increased blood flow on intimal hyperplasia in porous polytetrafluoroethylene grafts implanted in baboons. These grafts develop an endothelial lining by 2 weeks and neointimal thickening due to proliferation of underlying smooth muscle cells by 1 mont...
متن کاملShear stress regulates smooth muscle proliferation and neointimal thickening in porous polytetrafluoroethylene grafts.
High shear stress appears to decrease wall thickening in diseased arteries and vascular grafts. To determine if increased shear stress diminishes smooth muscle (SMC) proliferation, we studied the effect of increased blood flow on neointimal thickening in porous polytetrafluoroethylene grafts implanted in baboons. An aorto-aortic 5-mm graft was placed in tandem with a pair of aorto-iliac 5-mm gr...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2001
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2001.00750.x